Endocrine Abstracts

The ability of thyroid cell to accumulate iodine is due to presence of sodium iodide symporter (NIS). Differentiated thyroid cancer (DTC) maintain ability to express NIS and thus it makes possible to perform RAI treatment. In case of DTC cells loss the ability of NIS protein production and cell membrane embedding that leads to RAI treatment fail.The aim of our study was to find a relationship between the level of preoperatively defined NIS and recurrence...

Purpose: To assess the utility of BRAFV600E mutation detection in preoperative thyroid cancer diagnostic.Materials and methods: We studied 46 aspirates taken by FNA from patients with thyroid gland nodes. Thyroid tissue aspirates DNA was extracted by sorbent method. BRAF gene mutation was analyzed with primers specific for wild and mutant gen type by RT-PCR.Results: All patients were divided into three groups by cytological conclus...

There were evaluated galectin-3 expression in 66 fine-needle aspiration biopsy (FNAB) specimens from patients with thyroid gland nodules by flow cytometry method. We include in our study 29 patients with papillary thyroid cancer (PTC), 31 – with follicular neoplasia, 6 – with nodular colloid goiter by cytological examination. For specimens analysis, taken by FNAB of thyroid gland nodules, were used indirect immunofluorence method /Coons/.Result...

Hypothesis: The clinical presentation of primary hyperparathyroidism (PHPT) changed lately but we don’t know if more patients in our population have asymptomatic form of PHPT.Materials and methods: Medical records of 449 patients with PHPT who were operated in three Medical Centers (Saint-Petersburg, Russia) between Jan 2011– Jun 2018 were screened. We analyzed anthropometric data, laboratory tests (PTH, 25(OH)D, Ca, iCa, P, 24-h calciuria, ALP...